Answers for Medical Finals Quiz September 2006

Below are the author's answers and teaching points for this Quiz.


Question 1

A 54 year-old woman is admitted with right loin pain and haematuria. Tenderness in the right loin is found on examination.

A computed tomography scan of kidneys, ureters and bladder (CT-KUB) is performed (see below). A right renal tract calculus is observed.

CT-KUB

What is the most common location for renal tract calculi?

(a) Renal pelvis
(b) Mid-ureter
(c) Vesicoureteric junction
(d) Pelvicoureteric junction
(e) Bladder
Answer: (c) Vesicoureteric junction

CT-KUB is the first line imaging modality in most centres for patients with renal colic, although intravenous urography (IVU) is still used in some hospitals. A plain abdominal radiograph is of limited use in acute renal colic, but may be used to monitor a known radio-opaque calculus.

Renal calculi come in various types (see box)

Types of renal tract calculi:
  • Calcium Oxalate (majority)
  • Triple Phosphate
  • Uric Acid
  • Cysteine
  • Xanthine

The 3 most common locations for renal calculi (from proximal to distal) within the renal tract are:

  • Pelvico-ureteric junction
  • Within the ureter at the pelvic brim
  • Vesico-ureteric junction (the commonest)


Question 2

A patient has been treated with various drugs including gold injections for joint disease. She has now developed bronchiectasis.

Which of the following blood results would be in keeping with this information?

(a) Low immunoglobulins
(b) Positive urinary Bence-Jones protein
(c) Positive anti-double stranded DNA antibody
(d) Positive anti-nuclear antibody
(e) Positive Rheumatoid factor
Answer: (a) Low immunoglobulins

Some drugs including gold can cause an acquired immunodeficiency leading to low levels of immunoglobulins. This in turns predisposes to repeated infections. Recurrent respiratory tract infections can eventually lead to scarring and dilatation of distal airways. This eventually causes them to fill with mucous which subsequently becomes infected - this is bronchiectasis.

Common Causes of Bronchiectasis:
  • Immunodeficiency states
  • Measles or rubella infection
  • Tuberculosis
  • Suppurative lung diseases eg. Cystic fibrosis

Bence Jones protein is a urine test useful in the diagnosis of multiple myeloma. Anti-double stranded DNA antibody is a very specific test for systemic lupus erythematosus. Anti-nuclear antibody is positive in several immunological conditions.


Question 3

The clinician looking after a 73 year-old man with newly diagnosed iron deficiency anaemia is worried about the part of the bowel shown in this barium enema.

Bowel Enema

What diagnosis is he most worried about?

(a) Colonic Crohn's disease
(b) Caecal lymphoma
(c) Crohn's disease of terminal ileum
(d) Caecal carcinoma
(e) Tuberculosis of terminal ileum
Answer: (d) Caecal carcinoma

Colorectal malignancy is one of the commonest malignancies in the UK population.

In terms of presentation they can be divided into LEFT and RIGHT sided tumours.

The presenting symptoms differ, with some overlap, as shown in the boxes.

Symptoms of Colonic Carcinoma
Left Sided Tumours:
  • Tenesmus
  • Altered bowel habit
  • Weight loss
  • Rectal bleeding
Right Sided Tumours:
  • Iron deficiency anaemia
  • Mass in the right iliac fossa
  • Weight loss
  • Altered bowel habit

On a barium enema, caecal carcinoma is observed as a filling defect within the bowel (the barium contrast being unable to fill the luminal part of the caecum occupied by the tumour mass).

The commonest part of the large bowel to be affected by Crohn's disease is the ileo-caecal segment.


Question 4

A 46 year-old solicitor complains of right upper quadrant pain and has deranged liver function tests. An ultrasound scan of the abdomen demonstrated a dilated common bile duct. He proceeds to endoscopic retrograde cholangio-pancreatography (ERCP).

Whilst observing the procedure, the consultant in charge asks you the location of the Ampulla of Vater.

Where does the ampulla of Vater enter the bowel?

(a) Jejunum
(b) Ascending (fourth part) duodenum
(c) Descending (second part) duodenum
(d) Inferior (third part) duodenum
(e) Superior (first part) duodenum
Answer: (c) Descending (second part) duodenum

The small intestine is composed of the duodenum, jejunum and ileum.

The duodenum is divided into 4 parts: ascending, descending, inferior and superior. The duodenum is C-shaped the first part often being referred to as the duodenal cap.

The confluence of the common bile duct and pancreatic duct enters the descending (second part) of the duodenum as the Ampulla of Vater (major duodenal papilla).

The side viewing aspect of the ERCP endoscope is used to cannulate the Ampulla of Vater allowing access to the biliary tree.


Question 5

A patient with inflammatory arthritis develops an acutely swollen, painful hot elbow 2 days following an intra-articular steroid injection.

What is the most appropriate initial course of action?

(a) Blood cultures, repeat joint aspiration and intravenous antibiotics
(b) Repeat steroid injection
(c) Send serum urate and start colchicine
(d) Increase oral steroid and methotrexate
(e) Immobilise the joint
Answer: (a) Blood cultures, repeat joint aspiration and intravenous antibiotics

Introducing infection is a serious complication of intra-articular steroid injection. This is why it is very important to use aseptic technique. Septic arthritis needs prompt treatment with intravenous antibiotics to reduce long term damage to the joint.


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